![]() The first subunit comprises one polypeptide that can be any one of four polypeptides. The methanol dehydrogenase comprises two subunits, a first subunit and a second subunit. In one aspect, the bacterium produces methanol dehydrogenase, wherein the methanol dehydrogenase oxidizes methanol into formaldehyde. The term “subject” includes domesticated animals, such as cats, dogs, etc., livestock (e.g., cattle, horses, pigs, sheep, goats, etc.), and laboratory animals (e.g., mouse, rabbit, rat, gerbil, guinea pig, etc.). Preferably, the subject is a mammal such as a primate, and, more preferably, a human. As used herein, by “subject” is meant an individual. These Gram-negative rods were isolated from three cervical lymph nodes from a subject diagnosed with chronic granulomatous disease (CGD) and were cultured on BCYE plates (Remel) after four days' incubation at 35° C. Therefore, the Gram-negative bacterium of the present invention can grow in the presence of methanol, but the bacterium does not require methanol to grow. Thus, for example, a facultative methylotroph is a bacterium that can grow either in the presence or in the absence of methanol. As used herein, a “methylotroph” is a bacterium that can use methanol as a source of energy. As used herein, “facultative” means not required or compulsory. An example of the bacterium is designated Granulibacter bethesdensis, having the ATCC patent deposit designation BAA-1260. Provided herein is an isolated Gram-negative bacterium, wherein the bacterium is an aerobic, facultative methylotroph that produces colonies that are yellow pigmented, wherein the bacterium can use methanol as a sole carbon source and can oxidize glucose and ethanol into acid.
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